1.
Acta Pharm Sin B
; 12(9): 3739-3742, 2022 Sep.
Article
in English
| MEDLINE | ID: covidwho-1944219
2.
Chem Sci
; 12(42): 14098-14102, 2021 Nov 03.
Article
in English
| MEDLINE | ID: covidwho-1472230
ABSTRACT
The SARS-CoV-2 3-chymotrypsin-like protease (3CLpro or Mpro) is a key cysteine protease for viral replication and transcription, making it an attractive target for antiviral therapies to combat the COVID-19 disease. Here, we demonstrate that bismuth drug colloidal bismuth subcitrate (CBS) is a potent inhibitor for 3CLpro in vitro and in cellulo. Rather than targeting the cysteine residue at the catalytic site, CBS binds to an allosteric site and results in dissociation of the 3CLpro dimer and proteolytic dysfunction. Our work provides direct evidence that CBS is an allosteric inhibitor of SARS-CoV-2 3CLpro.
3.
Signal Transduct Target Ther
; 6(1): 230, 2021 Jun 10.
Article
in English
| MEDLINE | ID: covidwho-1387230
4.
Signal Transduct Target Ther
; 6(1): 198, 2021 05 18.
Article
in English
| MEDLINE | ID: covidwho-1387225